(0652) Thalidomide

An inhibitor, supplied by Tocris Bioscience, cited in 16 publications, with Pubchem CID 5426. Applications used include FC/FACS and IHC-IF.

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General Information

Supplier

Tocris Bioscience

PubChem CID

Function

Inhibitor

ChEBI ID

CHEBI:74947

Molecular Weight

258.23 g/mol

InChIKey

UEJJHQNACJXSKW-UHFFFAOYSA-N

IUPAC Name

2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione

Common Name

Thalidomide

Synonyms

Algosediv, Asidon 3, Asmadion, Bonbrain, Contergan, Corronarobetin, Distaval, Ectiluran, Enterosediv, Gastrinide, Grippex, Hippuzon, Imida-lab, Imidan (peyta), Isomin, K 17, Kevadon, Neaufatin, NeO, Nibrol, Noctosediv, Noxodyn, NSC-66847, Pangul, Pantosed

Supplier provided information

Applications

None provided

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16 citations

found in the literature

Applications

FC/FACS
IHC-IF

Dilutions

None Available

Published images

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Immunomodulatory imide drugs inhibit human detrusor smooth muscle contraction and growth of human detrusor smooth muscle cells, and exhibit vaso-regulatory functions.

In Biomedicine Pharmacotherapy = Biomédecine Pharmacothérapie on 1 August 2024 by Tamalunas, A., Wendt, A., et al.

Applications:

FC/FACS and IHC-IF

The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma.

In Molecular Cell on 18 March 2021 by Heider, M., Eichner, R., et al.

Inhibitors of ubiquitin E3 ligase as potential new antimalarial drug leads.

In BMC Pharmacology Toxicology on 2 June 2017 by Jain, J., Jain, S. K., et al.

Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration.

In The Journal of Biological Chemistry on 12 August 2016 by Del Prete, D., Rice, R. C., et al.

Immunomodulatory drugs target IKZF1-IRF4-MYC axis in primary effusion lymphoma in a cereblon-dependent manner and display synergistic cytotoxicity with BRD4 inhibitors.

In Oncogene on 7 April 2016 by Gopalakrishnan, R., Matta, H., et al.

Additive Renoprotection by Pioglitazone and Fenofibrate against Inflammatory, Oxidative and Apoptotic Manifestations of Cisplatin Nephrotoxicity: Modulation by PPARs.

In PLoS ONE on 5 November 2015 by Helmy, M. M., Helmy, M. W., et al.

γ-Tocotrienol but not γ-tocopherol blocks STAT3 cell signaling pathway through induction of protein-tyrosine phosphatase SHP-1 and sensitizes tumor cells to chemotherapeutic agents.

In The Journal of Biological Chemistry on 22 October 2010 by Kannappan, R., Yadav, V. R., et al.

Intraperitoneal injection of thalidomide attenuates bone cancer pain and decreases spinal tumor necrosis factor-α expression in a mouse model.

In Molecular Pain on 5 October 2010 by Gu, X., Zheng, Y., et al.

Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP-1 in human multiple myeloma cells.

In International Journal of Cancer on 15 July 2010 by Pandey, M. K., Sung, B., et al.

Effect of thalidomide and arsenic trioxide on the release of tumor necrosis factor-α and vascular endothelial growth factor from the KG-1a human acute myelogenous leukemia cell line.

In Oncology Letters on 1 July 2010 by Girgis, E. H., Mahoney, J. P., et al.