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Comments

(SML1105) UCF-101

A bioactive compound which acts as an inhibitor, supplied by SIGMA, cited in 15 publications, with Pubchem CID 71434047. Applications used include WB and ICC-IF.

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Supplier info
7 images
15 citations

General Information

Supplier
SIGMA
PubChem CID
71434047
Classification
Bioactive compound
Function
Inhibitor
Previous Suppliers
Sigma-Aldrich
Molecular Weight
497.5 g/mol
InChIKey
QMGXAGWZCHDZRG-UHFFFAOYSA-N
IUPAC Name
5-[[5-[2-(dihydroxyamino)phenyl]furan-2-yl]methylidene]-1,3-diphenyl-2-sulfanylidene-1,3-diazinane-4,6-dione
Common Name
Omi/HtrA2 Protease Inhibitor, Ucf-101

Supplier provided information

Applications

None provided


Additional product information

Supplier also known as

Millipore, Sigma Aldrich, Merck, Roche, Novagen, EMD

Previous Suppliers

Sigma-Aldrich


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7 images
15 citations

found in the literature

Applications
  • WB
  • ICC-IF
Dilutions
  • None Available

Loading published images for this product

A new function for the serine protease HtrA2 in controlling radiation-induced senescence in cancer cells.

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In Molecular Oncology on 1 March 2022 by Hammer, L., Levin-Salomon, V., et al.

Applications:

ICC-IF and WB

Images:

Intramitochondrial proteostasis is directly coupled to α-synuclein and amyloid β1-42 pathologies.

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In The Journal of Biological Chemistry on 24 July 2020 by Lautenschläger, J., Wagner-Valladolid, S., et al.

The function of bacterial HtrA is evolutionally conserved in mammalian HtrA2/Omi.

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In Scientific Reports on 24 March 2020 by Chung, H. J., Jamal, M. A. H. M., et al.

Applications:

WB

Images:

Omi/HtrA2 Protease Associated Cell Apoptosis Participates in Blood-Brain Barrier Dysfunction.

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In Frontiers in Molecular Neuroscience on 12 March 2019 by Hu, Y., Bi, Y., et al.

Omi/HtrA2 Participates in Age-Related Autophagic Deficiency in Rat Liver.

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In Aging and Disease on 1 December 2018 by Xu, J., Jiao, K., et al.

Omi/HtrA2 Regulates a Mitochondria-Dependent Apoptotic Pathway in a Murine Model of Septic Encephalopathy.

In Cellular Physiology and Biochemistry on 5 October 2018 by Wang, P., Hu, Y., et al.

PDGFR and IGF-1R Inhibitors Induce a G2/M Arrest and Subsequent Cell Death in Human Glioblastoma Cell Lines.

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In Cells on 6 September 2018 by Carrasco-García, E., Martinez-Lacaci, I., et al.

p53-mediated activation of the mitochondrial protease HtrA2/Omi prevents cell invasion.

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In The Journal of Cell Biology on 31 March 2014 by Yamauchi, S., Hou, Y. Y., et al.

Syk activation of phosphatidylinositol 3-kinase/Akt prevents HtrA2-dependent loss of X-linked inhibitor of apoptosis protein (XIAP) to promote survival of Epstein-Barr virus+ (EBV+) B cell lymphomas.

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In The Journal of Biological Chemistry on 28 October 2011 by Hatton, O., Phillips, L. K., et al.

Melatonin ameliorates ischemic-like injury-evoked nitrosative stress: Involvement of HtrA2/PED pathways in endothelial cells.

In Journal of Pineal Research on 1 April 2011 by Han, F., Tao, R. R., et al.

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